https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41131 Wed 27 Jul 2022 11:10:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45274 Wed 26 Oct 2022 20:10:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32910 Wed 24 Nov 2021 15:51:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46481 Wed 24 May 2023 13:04:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35679 Wed 24 Jun 2020 09:57:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32928 Wed 17 Nov 2021 16:30:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14341 Wed 11 Apr 2018 16:06:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19642 Wed 11 Apr 2018 14:59:48 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14893 Wed 11 Apr 2018 14:56:12 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30241 Wed 11 Apr 2018 14:56:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14897 R1) signaling within the ventral tegmental area (VTA) alters Fos-protein expression in relapse-relevant regions, including the PVT and the nucleus accumbens shell (NacS). Further, whilst previous findings have shown that blockade of OX_R1 in the VTA prevents reinstatement of Cocaine seeking, we show here that this treatment does not affect natural reward seeking for sweetened condensed milk. In light of the reviewed body of literature, as well as the novel data presented, we discuss the considerations for future pharmacotherapies targeting the orexin and CART systems for relapse prevention.]]> Wed 11 Apr 2018 14:47:04 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11120 Wed 11 Apr 2018 13:59:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14892 Wed 11 Apr 2018 13:50:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27445 Wed 11 Apr 2018 12:10:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14889 Wed 11 Apr 2018 11:53:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14350 +). The effect of VTA-directed injections of SB-334867 (0 or 3 μg) on locomotor activity was also assessed. Intra-VTA, but not -PVT, SB-334867 dose-dependently attenuated S⁺-induced reinstatement (3 μg dose, p<0.01). Intra-VTA SB-334867 had no effect on locomotor activity. We conclude that OrxR1 signalling within the VTA, but not the PVT, mediates cue-induced cocaine-seeking behaviour. We hypothesize that blockade of VTA OrxR1 signalling may reduce nucleus accumbens dopamine in response to drug cue presentation.]]> Wed 11 Apr 2018 11:48:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14891 Wed 11 Apr 2018 11:35:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14894 Wed 11 Apr 2018 10:51:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15458 Wed 11 Apr 2018 10:32:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15926 Wed 11 Apr 2018 10:07:44 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14895 Wed 11 Apr 2018 09:14:41 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27809 Wed 02 Mar 2022 14:24:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54411 Tue 27 Feb 2024 13:54:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32927 Tue 14 Aug 2018 14:59:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35731 in-vivo, including in animals with cocaine experience. First, we verified that group III mGluRs regulate orexin cell activity in behaving animals by showing that intra-LHA infusions of the selective agonist L-(+)-2-Amino-4-phosphonobutyric acid (L-AP4) reduces c-fos expression in orexin cells following 24 h food deprivation. Next, we extended these findings to show that intra-LHA L-AP4 infusions reduced discriminative stimulus-driven cocaine-seeking following withdrawal. Importantly, L-AP4 had no effect on lever pressing for sucrose pellets or general motoric behavior. Finally, using whole-cell patch-clamp recordings from identified orexin cells in orexin-GFP transgenic mice, we show enhanced presynaptic drive to orexin cells following 14d withdrawal and that this plasticity can be normalized by L-AP4. Together, these data indicate that activation of group III mGluRs in LHA reduces orexin cell activity in vivo and may be an effective strategy to suppress cocaine-seeking behavior following withdrawal. These effects are likely mediated, at least in part, by normalization of presynaptic plasticity at orexin cells that occurs as a result of cocaine exposure. This article is part of the Special Issue entitled ‘Hypothalamic Control of Homeostasis’.]]> Thu 28 Oct 2021 13:02:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45401 Thu 27 Oct 2022 17:29:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47122 Thu 23 Mar 2023 09:45:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36090 Thu 17 Mar 2022 14:39:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44060 Thu 06 Oct 2022 10:19:32 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55040 Thu 04 Apr 2024 13:51:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:912 Sat 24 Mar 2018 08:29:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20866 Sat 24 Mar 2018 07:57:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28072 Sat 24 Mar 2018 07:39:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23723 Sat 24 Mar 2018 07:16:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24946 Sat 24 Mar 2018 07:14:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45783 Sat 05 Nov 2022 12:42:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53155 Vglut2+) to the medial insular cortex in this behavior. Whole brain activation mapping and hierarchical clustering of Euclidean distances revealed distinct patterns of coactivation unique to stress-induced binge eating. At a pathway-specific level, PVT^Vglut2+ cells projecting to the medial insular cortex were specifically activated in response to stress-induced binge eating. Subsequent chemogenetic inhibition of this pathway suppressed stress-induced binge eating. We have identified a distinct PVT^Vglut2+ to insular cortex projection as a key driver of "emotional" stress-induced binge eating in female mice, highlighting a novel circuit underpinning this sex-specific behavior.]]> Mon 27 Nov 2023 15:54:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50935 Mon 14 Aug 2023 12:29:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34336 Mon 04 Mar 2019 12:02:55 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37792 Food-pics and internet sources), representative of healthy and hyperpalatable foods commonly consumed in Australia, was compiled by research dietitians. Ten male and female adults volunteered to view the images. Participants categorised each image as either healthy food or 'junk food' (i.e. hyperpalatable food), and rated each image according to three criteria: 1) familiarity of the food displayed; 2) recognisability of the food; and 3) appetisingness of the food. Overall, agreement with a priori categories was high for both healthy and hyperpalatable food images, 87.3% and 87.7% respectively. The food images with the lowest overall ratings (score <7 out of possible 9) were removed from the dataset and the final paradigms each contain 75 images. The healthy food paradigm contains foods from the five core food groups (fruit, vegetables, grains and cereals, meat and meat alternatives, dairy foods), and the hyperpalatable food paradigm contains non-core foods (sweet and savoury discretionary choice foods). The paradigms represent a broad range of commonly consumed foods that will be relevant for prospective projects utilising food cues in Australian adults.]]> Fri 23 Apr 2021 14:55:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37785 2 = 0.32, p = 0.021) at baseline. Oxytocin levels were higher, and cholecystokinin levels lower, in food addicted (n = 6) vs. non-food addicted females (p = 0.015 and p<0.001, respectively). There were no significant changes (p>0.05) in plasma oxytocin levels in response to either healthy or hyperpalatable food images. Given that endogenous oxytocin administration tends to suppress eating behaviour; these data indicate that oxytocin receptor desensitization or oxytocin resistance may be important factors in the pathogenesis of obesity and food addiction. However, further studies in larger samples are needed to determine if peripheral oxytocin is responsive to visual food cues.]]> Fri 23 Apr 2021 14:41:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37784  0.05) through altered diet or behaviors (neutral effect); in contrast, significant (P < 0.05) differences (increases and decreases) were identified in clinical samples. Exogenous oxytocin studies (n = 13) found reduced indices of food intake (positive effect) in clinical and nonclinical samples. Conclusions: Overall, few studies included comprehensive investigation of dietary intakes through the use of validated assessment tools. Dietary intake and behaviors appear to have some influence on oxytocin, with more pronounced effects found with exogenously administered oxytocin.]]> Fri 23 Apr 2021 14:34:22 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51705 Fri 15 Sep 2023 14:03:12 AEST ]]>